The following polar plots describe the receptor binding properties of various antipsychotics. These data were derived from Roth et al. Nature Reviews Drug Discovery 2004:3;353-359.

Receptor Profiles by Medication

The magnitude of each pole in the following plots represents a log scale of the estimated Ki for the ligand at each receptor type. Ki values were omitted because, well, when do you ever cite those when making clinical decisions? Poles are coloured by the neurotransmitter affected: serotonin (pink), noradrenaline (blue), dopamine (gold), histamine (green), acetylcholine (red-orange).

Receptor Profiles by Receptor

The magnitudes of the poles in the following plots represent the absolute Ki as reported by Roth et al.. The values were not include in the diagrams for the reasons stated above. Poles are coloured individually for each medication.